When slacker teen Anton Tobias (Devon Sawa) has his right hand possessed by a demonic force, he finds that his life gets a lot more interesting. While Anton himself is an amiable guy, his hand proves to be an appendage of death, killing his two best buddies, Pnub (Elden Henson) and Mick (Seth Green), who return to life as wisecracking zombies. In addition to murdering those closest to him, Anton's evil hand significantly hinders his chances with lovely neighbor Molly (Jessica Alba).